Changes in site and size of application of indomethacin onitment and percutaneous absorptions in rabbits

Abstract

The percutaneous absorption of indomethacin from ointment applied to the skin surface was influenced by the anatomical site of skin and the size of the application area. Dorsal sites led to higher levels than abdominal sites which in turn led to the higher levels than application to the thigh areas. The absorption increased in direct proportion to the size of the application area in the abdomen. The effects of different pH values of indomethacin solution in the onintment on the percutaneous absorption were examined. At a lower pH (7.07), there was good absorption.