Abstract
The present study was conducted to determine the changes in serum biochemical parameters and lipid profile by oral admini stration of ethanolic extract of P olyalthia cerasoides stem bark (PcEE 400 mg/kg b. wt) in streptozotocin (45 mg/kg b. wt) induced diabe tic rats. Albino rats of weighing between 200 - 230 g were induced with s ingle dose of streptozotocin (dissolved in 0.1 M ice cold citrate buffer (pH = 4.5) at a dose 45 mg/kg b. wt). Dia betes was confirmed after 48 h in streptozotocin induced rats showing fasting blood glucose levels ≥ 250 mg/dl. The rats w ere randomly divided into five groups (n = 6). Group I and II (normal and diabetic controls), Group III ( normal rats fed with 400 mg of PcEE), Group IV (diabetic rats fed with 400 mg of PcEE), Group V ( diabetic rats fed with 20 mg of Glibinclamide). After 2 1 days animals were sacrificed and blood samples were collected for biochemical analysis . T he results showed that the extract significantly (p < 0.05) reduced serum ALT, AST and ALP levels when compared to the diabetic control. The urea and creatinine levels are also controlled significantly ( P <0.05). Similarly TC, LDL, VLDL - cholesterol, TG and total lipids of serum were significantly ( P <0.05) decreased in streptozotocin induced diabetic rats but HDL - cholesterol levels remained un changed when compared to the diabetic control animals. The results clearly suggested that the extract has the ability to retain the altered biochemical parameters as nor mal in diabetic animals and tt was effective as glibinclamide treated animals. Hence th e study reveals the therapeutic use of PcEE on diabetes and its complications
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