Abstract
Toe influence of administration of natural prostaglandin F 2a (PgF) on plasma progesterone (P 4 ) and estradiol-1713 (E 2 ) levels during the last days of pregnancy (days 29-32) was studied in 13 doe rabbits of the California x New Zealand White breed. Animals were allocated to receive either a single intramuscular injection of 800 or 1200µg of natural PgF on day 29 of pregnancy at 10 h (treated groups) or no injection (control group). All does treated with PgF kindled within 60 h after injection, whereas the variation in birth time in control group was greater (79.2 ± 8.9 h). No influence of the prostaglandin treatment on mean plasma estradiol (5.2 pg/ml) and both litter size and born dead (7.2 ± 0.7 and 0.4 ± 0.6, respectively) was observed. A significant fall in progesterone concentration was defected in treated animals at 20 h on day 29 compared with control group (3.17 ± 0.22 and 3.47 ± 0.32 vs. 6.7 ± 1.4 ng/ml; P<0.05). Our results suggest that the induction of parturition with natural PgF has similar effects on plasma P 4 levels and in synchronization of parturitions to synthetic analogues, although the dose administered is greater.
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