Abstract
Changes in electrophysiological characteristics and ongoing activity parameters of the isolated rat retinal ganglion cells were evaluated 3-4 weeks after streptozotocin injection (80 mg/kg). It has been revealed that electrophysiological characteristics significantly decreased. In particular, density of sodium current decreased by 35% (from -0.84 ± 0.14 nA/pF in control to -0.55 ± 0.08 nA/pF in streptozotocin-induced diabetes mellitus; potassium current decreased by 36% (0.87 ± 0.14 in diabetes versus 1.36 ± 0.16 nA/pF in control, and resting membrane potential decreased by 10% (-53 ± 1 mV in diabetes versus -59 ± 1 mV in control. The mean frequency of ongoing postsynaptic currents was reduced by 72% (2...5 ± 0.3 sec-1 in control and 0.7 ± 0.1 sec-1 in diabetes. The data suggest that pathological changes in the electrophysiological characteristics of the rat retinal ganglion cells appear at the early stage of experimentally-induced diabetes mellitus.
Published Version
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