Abstract
The nucleic acid content of HeLa cells was determined at various times after exposure to a high multiplicity of herpes virus. The DNA content rose 6 to 9 hours after infection, before any increase in infective virus, which was just detectable at 12 hours. By 72 hours the cells contained nearly double their normal content of DNA. This increase in DNA was confined to the nucleus. No significant change in RNA content was observed.
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