Abstract
Summary The effect of Shigella shigae toxin on content of catecholamines and 5HT in the mouse brain, adrenals and heart was determined. It was found in the brain that a latency period of 48 hr precedes the lowering of the NA and 5HT content. The level of NA depjetion was found to be toxin dose-dependent. No changes in NA and A content could be found in the heart of Shigella shigae treated animals. In the adrenals 48 hr after toxin administration there is a significant lowering of adrenaline as well as noradrenaline content. The different response of various organs is discussed.
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