Abstract
This chapter provides an overview of the changes in murine lymphocyte surface topography induced by a friend virus infection. The infection of susceptible strains of mice with an oncornavirus, such as Friend leukemia virus (FLV), invariably results in marked immunodepression, which generally precedes the overt symptoms of disease, such as splenomegaly and blood cell dyscrasia. The chapter describes a study in which the surface topography of splenocytes in FLV-infected mice was examined by scanning electron microscopy. A correlation was readily made between the changes in the number of cells with distinctive topography and cells staining with fluoresceinated antibody to immunoglobulin or theta antigen. It was found from the study that within a few days after infection, the percentage of cells staining with these anti-FLV serums (reagents) decreased markedly. These results indicate that a marked alteration of cell types occurs in the spleen of FLV-infected mice and these changes correlate with an alteration of cell surface.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Leukocyte Membrane Determinants Regulating Immune Reactivity
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
