Abstract
Although the incidence of hepatobiliary enzyme abnormality increased immediately after the Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident, longer-term trends remain unclear. The aims of this study were to determine longer-term trends in hepatobiliary enzyme abnormality and to elucidate lifestyle factors associated with such changes among residents of a nuclear-disaster-affected area. This longitudinal survey enrolled 20,395 adults living in the vicinity of Fukushima Daiichi Nuclear Power Plant. Data were obtained from the records of annual health checkups of adults aged ≥40 years between 2011 and 2012. Follow-up examinations were conducted from June 2013 to March 2014. Associations were assessed between changes in hepatobiliary enzyme abnormality immediately and 3–4 years after the disaster and lifestyle factors. The overall prevalence of hepatobiliary enzyme abnormality significantly decreased over the study period, from 29.9% to 27.1%. Multivariate logistic regression analysis revealed significant associations between improved hepatobiliary enzyme abnormality and improvements in daily physical activity and frequency of breakfast consumption. The results suggest that improvements in daily physical activity and frequency of breakfast consumption significantly reduced the incidence of hepatobiliary enzyme abnormality 3–4 years after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident.
Highlights
The early results of the FHMS have already shown increases in body weight and higher incidences of diabetes, dyslipidemia, atrial fibrillation, hypertension, renal dysfunction and metabolic syndrome among residents of the disaster-affected area[2,3,4,5,6,7,8]
This study investigated trends associated with hepatobiliary enzyme abnormality after the Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident
Male sex, increased body mass index (BMI), and evacuation were identified as risk factors for the development of hepatobiliary enzyme abnormality
Summary
The early results of the FHMS have already shown increases in body weight and higher incidences of diabetes, dyslipidemia, atrial fibrillation, hypertension, renal dysfunction and metabolic syndrome among residents of the disaster-affected area[2,3,4,5,6,7,8]. According to the FHMS, a higher incidence of hepatobiliary enzyme abnormality was observed immediately after the Great East Japan Earthquake, from 2011–20129. Previous assessments of hepatobiliary enzyme abnormality using FHMS data were based on comparisons of incidences before and after the disaster[2,3,4,5,6,7,8,9,10], and the results reflected relatively short-term effects; longer-term effects of the disaster on and lifestyle factors associated with hepatobiliary enzyme abnormality unclear. The objectives of the present study were to determine longer-term trends in hepatobiliary enzyme abnormality and to elucidate lifestyle factors associated with such changes among residents of Fukushima Prefecture 3–4 years after the Great East Japan Earthquake
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