Changes in constituents in arterial blood following experimentally induced epileptic convulsion in dogs.

Abstract

1. Hematocrit value, pH, chloride, sugar, inorganic phosphate and acid-soluble organic phosphorus in arterial blood of dogs were successively determined before and after the electrically induced convulsions and the following results were obtained. 2. The hematocrit value increased abruptly within 2-3 minutes and sustained the maximum value for more than 10 minutes, then returned towards normal at 30 minutes after the convulsion. 3. pH in the plasma decreased, attaining the minimum value at about 2-3 minutes and returned to normal by 60 minutes after the convulsion. 4. The concentration of chloride in the blood increased soon after the electroshock, and showing an increase in the Donnan's ratio, then returned to the initial value within 30-60 minutes following the electrical stimulation. 5. A marked rise in the blood sugar was found immediately after the convulsion and then slowly decreased, but it remained at a level higher than the initial one even 60 minutes after convulsions. This rise was little affected by the bilateral splanchnicotomy, but almost abolished after adrenalectomy. 6. The concentration of the plasma inorganic phosphate increased remarkably after the convulsion, showing the maximum value at about 30 minutes, then gradually diminished, but did not return to normal even at 60 minutes after the convulsion. On the other hand, cell inorganic phosphate showed a slight increase. No significant change in the concentration of acid-soluble organic phosphorus in cells was found. 7. The changes in the constituents of arterial blood by electric convulsions were discussed with regard to the results obtained from the experiments on the emotional excitement, hard exercise and hemorrhagic shock in man and animals. The outline of this work was reported in the 28 th General Meeting of Japanese Physiological Association (1951).