Concentration of Chloride, Sodium and Potassium in Blood of Guinea Pigs Treated with Desoxycorticosterone Acetate.

Abstract

SummaryA group of castrated female guinea pigs was treated with fibromatogenic quantities of diethylstilbestrol; another group was treated simultaneously with diethylstilbestrol and quantities of desoxycorticosterone acetate sufficient to prevent estrogen-induced abdominal fibroids. The average fibrous tumoral effect diminished by the action of desoxycorticosterone from 5.5 to 1.7 units. Concentration of chloride, sodium and potassium in the blood of the groups treated with diethylstilbestrol, desoxycorticosterone or both was within the same range as in animals not treated. These results show that the antifibromatogenic quantity of desoxycorticosterone acetate is smaller than those doses which might interfere with the concentration of chloride, sodium or potassium in the blood.