Abstract
Objective: To compare changes in the concentrations of Lp(a) lipoprotein and other atherogenic lipids and lipoproteins in natural and hyperstimulated ovarian cycles. Design: Open, prospective study. Setting: Academic department in a teaching hospital. Patient(s): Normal ovulatory women served as controls and the treatment group consisted of women undergoing ovarian hyperstimulation. Intervention(s): The treatment group received hMG on a fixed regimen. Main Outcome Measure(s): Measurements of serum lipids and lipoproteins were made in both natural and hyperstimulated cycles. Result(s): There was a significant increase in the median concentration of Lp(a) lipoprotein from 10.1 to 10.7 mg/dL in the luteal compared with the proliferative phase of unstimulated cycles. In hyperstimulated cycles, there was a significant increase in the median concentration of Lp(a) lipoprotein from 9.7 mg/dL in the proliferative phase to 11.3 mg/dL in the luteal phase. Reductions in concentrations of total cholesterol and low-density lipoprotein cholesterol were found in the luteal phase of hyperstimulated cycles. Conclusion: Concentrations of Lp(a) lipoprotein increase during the luteal phase of both natural and hyperstimulated ovarian cycles.
Published Version
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