Abstract
Objective To evaluate the plasma level of amino-terminal pro-brain natriuretic peptide(NT-proBNP) before and after treatment in children with dilated cardiomyopathy(DCM) and explore the relationship between NT-proBNP and heart functional classes.To evaluate the significance of dynamic change in NT-proBNP level in children with dilated cardiomyopathy. Methods The study comprised 49 children with DCM from Aug.2011 to Sep.2013 in Hunan Children's Hospital.NT-proBNP levels were measured before and after treatment.All the patients were evaluated under the modified Ross Heart Association functional class and echocardiographic determination of left ventricular ejection fraction(LVEF) and fractional shortening(SF). The patients were divided into improvement group(38 cases) and the non-improvement group(11 cases) according to cardiac function after treatment. Results The plasma level of NT-proBNP was positively correlated with Ross heart failure classification(r=0.756, P<0.01), and much better than LVEF and SF.To identify mild heart failure, the cut-off value of 329 ng/L was 93.8% sensitive and 90.9% specific.To identify moderate heart failure, the cut-off value of 2 833 ng/L was 95.6% sensitive and 92.9% specific.To identify severe heart failure, the cut-off value of 12 125 ng/L was 80.6% sensitive and 84.8% specific.There was significant difference in the improvement group before and after treatment(t=2.357, P<0.05). In non-improvement group there was no significant difference (t=0.132, P=0.778) before and after treatment. Conclusions There is significant correlation between the plasma level of NT-proBNP and heart failure severity.The dynamic changes in NT-proBNP levels before and after treatment can help us to determine the effect of treatment and prognosis. Key words: N-terminal pro-brain natriuretic peptide; Dilated cardiomyopathy; Heart failure
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
