Changes in adiposity and other cardiometabolic risk factors following Roux-en-Y gastric bypass: A 12-month prospective cohort study in Chinese patients.

Abstract

We aimed to investigate the changes in adiposity and other cardiometabolic risk factors in the year following Roux-en-Y gastric bypass (RYGB) in patients of Chinese ethnicity. The study recruited 209 patients who met the indications for bariatric surgery. Adiposity and cardiometabolic risk factors were assessed at baseline and over the 12months following surgery in all participants. SPSS® software was used for statistical analysis. The mean body mass index (BMI) was 29.98kg/m2 at baseline and steadily decreased to 25.32kg/m2 at 12months, giving a relative change of -15.5% (p<0.001). All of the lipid profile fractions except high-density lipoprotein (HDL) declined during the first 12months of follow up; serum HDL increased during this time (all ANOVA p<0.001). The mean fasting plasma glucose was 9.49mmol/L at baseline and gradually decreased to 5.69mmol/L at 12months, giving a relative change of -40.0% (p<0.001). Following the RYGB procedure, changes in measures of adiposity were paralleled by a significant improvement in cardiometabolic factors for 12months after surgery.