Changes and significance of serum levels of YKL-40, Ig G, and complement C4 in children with recurrent pneumonia

Abstract

Objective To study the changes and significance of serum levels of YKL-40, Ig G, and complement C4 in children with recurrent pneumonia. Methods 42 children with recurrent pneumonia treated our department from January to October, 2016 were selected as an observation group and 42 healthy children without any lung disease taking physical examination a control group. The serum levels of YKL-40, Ig G, and complement C4 were detected in both groups. Results The serum levels of YKL-40 and Ig G1 were obviously higher and the serum levels of C4, IgG2, and IgG4 were lower in the observation group than in the control group [ (55.63±4.87) ng/ml vs. (29.98±5.42) ng/ml, (6.24±0.25) g/L vs. (5.22±0.31) g/L, (0.19±0.04) g/L vs. (0.31±0.06) g/L, (2.07±0.38) g/L vs. (2.83±0.26) g/L, and (0.16±0.03) g/L vs. (0.28±0.07) g/L], with statistical differences (all P 0.05) . Conclusion The changes of serum levels of YKL-40, Ig G, and complement C4 in children with recurrent pneumonia are the results of the immune response to inflammation in the children’s body and can be used for the diagnosis of recurrent pneumonia in children. Key words: Recurrent pneumonia; YKL-40; Ig G; complement C4; Change