Abstract
Objective To investigate the effect of autoantibody and serum C3 and C4 levels on the diagnostic sensitivity and specificity of systemic lupus erythematosus (SLE). Methods Fifty-seven patients with SLE were selected as the observation group, and 57 healthy subjects were selected as the control group. Both groups were collected venous blood 3 ml after admission; and the supernatant was abstracted after centrifugation; anti-ds-DNA antibody was detected by enzyme-linked immunosorbent assay; anti-nucleosome antibody, anti-ribosomal P protein antibody, anti-sm antibody were detected by linear immunoassay; and serum complement C3 and C4 were detected by scattering immunoturbidimetric assay. Results ① The positive rate of autoantibody of two groups: detection rates of anti-ds-DNA antibody, anti-nucleosome antibody, anti-ribosomal P protein antibody and anti-sm antibody in the observation group were 63.16% (36/57), 43.86 % (25/57), 31.58% (18/57), 26.32% (15/57); in the control group, the detection rate of anti ds-DNA antibody was 8.77% (5/57), and the anti nucleosome antibody, anti ribosomal P protein antibody and anti SM antibody were not checked out, the difference was significant (P 0.05). ③ Serum complement C3 and C4 levels of the two groups: the serum complement C3 and C4 levels in the observation group were lower than those in the control group, the difference was significant (P 0.05). ⑤ Autoantibody and serum complement test: autoantibody combined with serum complement detection sensitivity was higher than autoantibody or serum complement alone detection, and missed diagnosis rate was lower than autoantibody or serum complement alone test, the difference was significant (P 0.05). Conclusions Autoantibodies combined with serum C3 and C4 levels detection can effectively improve the detection sensitivity for SLE and reduce the rate of missed diagnosis, which is of great significance in the early diagnosis and treatment of disease. Key words: Systemic lupus erythematosus; Autoantibody; Complement C3; Complement C4; Sensitivity; Specificity
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