Changes and significance of P-selectin and PAC-1 in coronary heart disease before and after stenting

Abstract

To explore the platelet activation status before and after coronary artery stent implantation at different timepoints. The contents of CD62P (soluble P-selectin) and PAC-1 (platelet glycoprotein GPIIb/IIIa fibrinogen receptor) in patients after coronary stent implantation were detected by flow cytometry (FCM) before, immediately after surgery, postoperative 2, 4, 6 and 24 h in peripheral blood. In 65 cases, the levels of CD62P[40.63(25.14-51.01)%] and PAC-1[36.59(20.37-48.41)%] immediately after surgery were significantly higher than their preoperative values [14.79 (9.85-26.66) %, 13.99(11.42-30.133)%] (P < 0.05). And the postoperative levels of 2 h [8.64(4.48-15.67)%, 12.64(6.45-18.83)%], 4 h [7.91(4.56-12.94)%, 12.81(6.89-18.66)%], 6 h [6.53(4.12-9.27)%, 9.43(5.27-15.65)%] and 24 h [6.28(4.36-9.63)%, 10.38(4.63-18.11)%] decreased significantly versus their preoperative values (P < 0.05). Stenting of coronary endothelial damage within 2h may enhance platelet activation and boost the risk of thrombosis.