Changes and significance of early lactate level and lactate clearance rate in patients with cardiac arrest syndrome

Abstract

Objective To investigate the significance of early blood lactic acid and lactic acid clearance in patients with post-cardiac arrest syndrome(PCAS). Methods 87 cases were divided into the survival group(26 cases) and the death group(61 cases). The clinical data of two groups were analyzed statistically. Results The 6h blood lactate (8.46±2.37)mmol/L, 6h blood lactate clearance rate (34.53±14.75)%, the residual alkali (-3.08±3.68)mmol/L, 6h SevO2(68.35±6.33)%, APACHE Ⅲ score (19.64±2.48)points in the survival group were significantly better than those of the death group[blood lactic acid value (12.32±3.56)mmol/L, 6h blood lactate clearance rate (27.71±11.38)%, the residual alkali (-5.61±4.14)mmol/L, 6h SevO2(63.22±5.94)%, APACHEⅢ score (24.32±5.33)points], with significant differences between two groups(t=5.99, 2.36, 2.73, 3.66, 5.62, all P<0.05). The 6h blood lactate clearance rate, 6h SevO2 and APACHEⅢ score were independent risk factors for the prognosis of PCAS(OR=1.23, 1.64, 1.28, all P<0.05). Conclusion The early blood lactate clearance rate can be used as a sensitive indicator for evaluating the prognosis of PCAS. Key words: Cardiac arrest; Cardiac arrest syndrome; Lactic acid; Lactate clearance