Abstract
A change of conformational disorder in membrane lipids in a small piece of pulmonary artery tissue was monitored by measuring the change in peak position for the infrared absorbance of lipid methylene residues using Fourier transform infrared spectroscopy. The peak position was determined from the second-derivative spectrum of the artery tissue which was sandwiched by CaF 2 discs and set on a beam-condenser apparatus. Rats were injected with monocrotaline and 1, 2 and 4 weeks later the pulmonary arteries were subjected to infrared measurements. At 4 weeks after the injection a significant change in the peak position of the methylene infrared absorbance was detected at either 25 or 37°C. The shift of the peak to higher wavenumber suggested that the average conformational disorder in membrane lipids in the pulmonary artery in situ was increased by the monocrotaline treatment.
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