Abstract
Change for the Better: Phosphoregulation of Proteins Drives Evolution
Highlights
One hundred and fifty years after Charles Darwin proposed that ‘‘endless forms’’ of life, past and present, evolved by natural selection, researchers are still working out what processes generate the variation that natural selection operates on
One way to tackle these questions is by focusing on how proteins change over time, both at the level of the gene that encodes them and at the level of the protein itself, and how these changes affect basic cell functions. In this issue of PLoS Biology, Pedro Beltrao and colleagues describe the use of high-throughput mass spectrometry analysis to compare the phosphorylation status of proteins in three species of yeast
Selected PLoS Biology research articles are accompanied by a synopsis written for a general audience to provide non-experts with insight into the significance of the published work
Summary
One hundred and fifty years after Charles Darwin proposed that ‘‘endless forms’’ of life, past and present, evolved by natural selection, researchers are still working out what processes generate the variation that natural selection operates on. Armed with high-throughput genome sequencing tools, researchers today can ask how mutations generate positive outcomes in different species and which types of genes are most likely to change for the better. In this issue of PLoS Biology, Pedro Beltrao and colleagues describe the use of high-throughput mass spectrometry analysis to compare the phosphorylation status of proteins in three species of yeast.
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