Challenging perspectives: Prescribing hormone replacement in premature ovarian insufficiency

Abstract

The incidence of premature ovarian insufficiency (POI) is increasing in the general population with, among other reasons, more women surviving cancer treatments or having risk-reducing prophylactic oophorectomy due to BRCA status. The ovary is a vital endocrine gland and lost hormones need replacing to maintain system-wide health until the average age of the menopause (51 years). The combined oral contraceptive or hormone replacement therapy are recognised treatment choices for POI, but choosing the individual prescription may seen daunting. Through simple risk–benefit assessment and understanding modes of action, the nurse prescriber can guide effective decision-making and support long-term compliance.