Abstract
Since its inception, Compact Disc (CD)-based centrifugal microfluidic technology has drawn a great deal of interest within research communities due to its potential use in biomedical applications. The technology has been referred to by different names, including compact-disc microfluidics, lab-on-a-disk, lab-on-a-CD and bio-disk. This paper critically reviews the state-of-the-art in CD-based centrifugal microfluidics devices and attempts to identify the challenges that, if solved, would enable their use in the extreme point of care. Sample actuation, manufacturing, reagent storage and implementation, target multiplexing, bio-particle detection, required hardware and system disposal, and sustainability are the topics of focus.
Highlights
Recent developments in the area of Point of Care (POC) diagnostics and therapeutics have led many researchers, clinicians, policy makers, and lay people to explore the potential for these technological developments to bring relief to patients in the poorest, most remote areas of the globe.These areas of the world and clinical situations are referred to in this work as the extreme POC
This study revealed that Enzyme linked immunosorbent assay (ELISA) on a Compact Disc (CD) could lead to reduced reagent consumption which, when combined with reduced assay time, could prove valuable in the extreme POC environment
The above review of the literature points out many of the advantages that CD microfluidics could offer in applications at the extreme POC
Summary
Recent developments in the area of Point of Care (POC) diagnostics and therapeutics have led many researchers, clinicians, policy makers, and lay people to explore the potential for these technological developments to bring relief to patients in the poorest, most remote areas of the globe. These areas of the world and clinical situations are referred to in this work as the extreme POC. For the purpose of this work and future conversations, the authors are defining the extreme POC as healthcare environments without reliable electricity, clean water, sufficient healthcare or logistics infrastructure, sufficiently trained healthcare work force, monetary resources for sustainable health solutions, or combinations of these issues. Any diagnostic developed for the extreme POC should take into account the ASSURED criteria as defined by the World Health Organization [1]; where A stands for affordable,
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