Abstract
The introduction of molecular components has led to exponential growth in the field of allergy diagnosis over the last two decades and allergy testing is now more complex and comprehensive. Most specialists who do not deal with the management of allergy patients on a daily basis may find it difficult to stay up-to-date with current developments in the field, which, in practice, may lead to unnecessary or nontargeted testing. The primary objective of this review is to briefly summarise the major differences in past immunoglobulin E testing compared to modern methods. The secondary objective is to give an overview of approaches that are, in the authors’ opinions, worth considering as concepts because they address two fundamental issues in allergy management: how to relate results of immunoglobulin E testing to severity of symptoms, and how to increase the pretest probability of an allergy and facilitate management of an allergic patient.
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