Cα–H Oxidations of Amines to Amides: Expanding Mechanistic Understanding and Amine Scope through Catalyst Development

Abstract

This highlight provides a general overview of Cα–H oxidations of amines to form amides. Initial as well as recent examples are reviewed with a particular focus on existing challenges regarding substrate scope and reaction conditions. Finally, one very recently established catalyst system is described in detail which achieves the iron-catalyzed, Cα–H oxidation of amines under mild conditions. 1 Introduction 2 First C–H Oxygenations 3 State of the Art: Oxidations of Primary, Secondary, Cyclic, Benzylic, and Aromatic Amines 4 General Iron-Catalyzed C–H Oxidations under Mild Conditions 5 Conclusions