Abstract
Abstract Adipose tissue is a very important biologic component to nutrient storage and transport. The tissue and flow mechanics of the fluid within the extracellular space is not currently well understood, and difficult to study by experimentation, but could be studied through the development of a mathematical model of the anatomical domain. The study therefore was completed in order to develop a computational fluid dynamics (CFD) model to simulate the interstitial fluid flow in adipose tissue. Various characteristics of the tissue had to be defined by research and experimentation in order to create the model including, but not limited to, the domain size, tissue characteristics, capillarization within the tissue, and oncotic pressure distribution that drives the interstitial flow. The CFD model developed to simulate the interstitial flow within adipose tissue yielded a maximum fluid velocity of 1.85 μm/s, which was found to be within the range of published observed interstitial fluid flow velocities. Also, the model showed that capillarization of the tissue has a large effect the interstitial fluid flow mechanics and pattern in the extracellular space of the adipose tissue. This CFD model development could be used to further adipose tissue understanding as well as drug delivery kinetics in the region.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
