Abstract
PURPOSE Aerobic exercise is known to reduce blood cholesterol though the response is variable between individuals. Moreover, previous studies have produced equivocal results on the blood cholesterol response to resistance training (RET). The Cholesterol Ester Transfer Protein (CETP) gene contains a polymorphism that has been suggested to affect cholesterol metabolism and thereby blood cholesterol levels. METHODS We investigated whether the gene variant was associated to blood cholesterol responses in 91 young (18–30 years) adult men and women who participated in 10 weeks, 3 hrs/week of RET at 80% of one repetition maximum. Fasting blood samples were collected at baseline and at the end of RET. RESULTS At baseline, women (N=47) had significantly higher total (179±6 vs 165±6 mg/dl), and HDL cholesterol (54±10 vs 43±6), and lower Chol:HDL (3.4± vs 3.8±) than men (N=44). CETP genotype was significantly (P<0.05) associated to change in total (AA=−0.3±3.6, N=27, AG=−1.4±2.7, N=48, GG=13.5±4.8, N=15), HDL (AA=0.3± 1.1, AG=−0.5±.8, GG=3.4±1.5) and LDL (AA=1.4± 3.4, AG=−2.1±2.5, GG= 15.0±4.6) cholesterol. There were no significant interactions with gender. CONCLUSIONS These results suggest that the CETP genotype is associated with blood cholesterol response to RET.
Published Version
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