Certolizumab has favorable efficacy on preventing pancreas and target organs damage in acute pancreatitis

Abstract

Abstract Objective It was targeted to assess the efficacy of certolizumab on pancreas and target organs via biochemical parameters and histopathologic scores in experimental acute pancreatitis (AP) model in rats. Methods 40 male Sprague Dawley rats were divided into 5 equal groups: Group 1 (sham group), Group 2 (AP group), Group 3 (AP + low-dose certolizumab group), Group 4 (AP + high-dose certolizumab group), and Group 5 (placebo group). Rats in all groups were sacrificed 24 hours after the last injection and amylase, TNF-alpha, TGF-β, IL-1 β, MDA, SOD, and GPx levels were studied in blood samples. Histopathological investigation of both the pancreas and target organs (lungs, liver, heart, kidneys) were performed by a pathologist blind to the groups. In silico analysis were also accomplished. Results The biochemical results in the certolizumab treatment groups were identified to be significantly favorable compared to the AP group (p < 0.001). The difference between the high-dose group (Group 4) and low-dose treatment group (Group 3) was found to be significant in terms of biochemical parameters and histopathological scores (p < 0.001). In terms of the effect of certolizumab treatment on the target organs (especially on lung tissue), the differences between the low-dose treatment group (Group 3) and high-dose treatment group (Group 4) with the AP group (Group 2) were found to be significant. Conclusion Certolizumab has favorable protective effects on pancreas and target organs in AP. It may be a beneficial agent for AP treatment and may prevent target organ damage.