Abstract
Bone cement with photothermal properties can treat bone defects caused by bone tumors while killing residual tumor cells or preventing recurrence. In this study, trace amounts of cerium ions were introduced to enhance the crystal stability of α-TCP, thereby improving the hydration properties of α-TCP and obtaining excellent photothermal properties. The experimental results showed that the content of α-TCP in CON-TCP was 96.05 %, and the content of α-TCP in 1% Ce-TCP was 99.77 %, with an increase of 3.87 %; the compressive strength of 0.5% Ce-CPC hydrated for 5d increased from 16.6 MPa±2.18 MPa to 32.16 MPa±2.77 MPa, with an increase of 93.73 %. The temperature of 0.5% Ce-CPC can be raised to 50.9°C in two minutes under the irradiation of 808 nm laser, which is an increase of 31.5% compared with that of 38.7°C in the blank group. Therefore, trace cerium-doped calcium phosphate bone cement has excellent physicochemical and photothermal properties, and it is a promising composite bone cement material, and the results of the present study are expected to be used to treat bone defects in bone tumors.
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