Abstract
In recent years, mesoporous bioactive glass nanoparticles (MBGNPs) have generated great attention in biomedical applications. In this study, cerium and gallium doped MBGNPs were prepared by microemulsion assisted sol-gel method in the binary SiO2-CaO system. MBGNPs with spheroidal and pineal shaped morphology were obtained. Nitrogen sorption analysis elucidated the mesoporous structure of synthesized nanoparticles with high specific surface area. X-ray diffraction analysis confirmed the amorphous nature of the nanoparticles. The chemical compositions of all samples were determined by inductively coupled plasma-optical emission spectrometry (ICP-OES), which revealed that the contents of cerium and gallium could be tailored by adjusting the concentrations of the precursors used for the synthesis. All MBGNPs exhibited in vitro bioactivity when immersed in simulated body fluid, except the particles doped with higher amounts than 1 mol% of cerium. MBGNPs showed antibacterial activity against S. aureus and E. coli without exhibiting cytotoxicity towards MG-63 osteoblast-like cells. Mentioned features of the obtained Ce and Ga-doped MBGNPs make them useful for multifunctional applications such as drug delivery carriers or bioactive fillers for bone tissue engineering applications.
Highlights
Bioactive glasses (BGs) are being increasingly considered in a variety of biomedical applications including in mesoporous particulate form [1,2,3,4,5]
The micro emulsion assisted sol-gel method allowed the preparation of mesoporous bioactive glass nanoparticles (MBGNPs) with a spherical shape, homogeneous size distribution, and a low degree of agglomeration
The shape of MBGNPs changed from elon gated pineal to spherical with the decrease of the amount of calcium nitrate
Summary
Bioactive glasses (BGs) are being increasingly considered in a variety of biomedical applications including in mesoporous particulate form [1,2,3,4,5]. MSNs exhibit interaction with tissues at the cellular level and directly with the extracellular matrix [9,10,11,12] Such MSNs are of great interest, they have not yet been approved by regulatory agencies for biomedical applications. Soluble and biodegrad able BGs have been considered for clinical applications for over 30 years with Na, Ca, and P being the elements added to silica in standard (45S5) BG [14]. In this sense, the addition of cations like Ca2+ can alter MSNs degradation rate, affecting the fate of MNPs in the body [13]. The addition of metallic ions affects the surface charges of silica nanoparticles, which can result in their aggregation, disturbing their growth [15]
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