Abstract
Focal cerebral ischemia produces heterogeneous alterations in the cerebral circulation and metabolism, which eventually lead to the development of ischemic brain damage. It is not, however, in the period after irreversible brain damage is established that brain water is increased. Early ischemic oedema seems rather to be a reversible functional event, in which a change in the permeability of the blood-brain barrier (BBB) to cations is involved through unknown mechanisms of brain capillary function. In the later stage, however, when gross changes in the BBB are induced, the development of brain oedema may well be linked with that of ischemic brain damage. Therefore, an important question at this stage is whether brain oedema itself has neuropathologic consequences. Since no correlative investigations have so far been published, we report here topographical alterations and the correlation between IBD and oedema formation following occlusion of the middle cerebral artery (MCA) in the rat.
Published Version
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