Abstract
BackgroundAssociations between serum phosphorus level and the incidence of ischemic stroke are not clear. This study aimed to measure serum phosphorus, vitamin D3, and uric acid levels in ischemic stroke patients compared to a population without ischemic stroke.MethodsIn this cross-sectional study, 133 patients admitted to a neurology ward with the diagnosis of ischemic stroke were compared with a control group comprising 133 age- and gender-matching individuals. The presence of ischemic stroke was confirmed by a neurologist based on clinical signs, symptoms, brain CT scan, and MRI. Blood samples were taken from all patients in the first 24 h of admission to measure serum phosphorus, vitamin D3, calcium, and uric acid levels.ResultsAccording to the results of this study, uric acid medians in patients with stroke and controls were 4.9 [3.8–6.4] and 3.9 [3.5–4.9] mg/dL, respectively (p < 0.001). Median phosphorus and vitamin D levels were significantly lower in stroke patients than the controls (3.6 [3.02–4.21] vs. 4.2 [3.8–4.6]) and (15.1 [8.2–27.9] vs. 22.7 [10.4–39.2]), respectively. Multiple logistic regression analysis showed that the ischemic stroke was positively associated with the vitamin D level and negatively correlated with the uric acid level. The phosphorus level was not significantly predictive of ischemic stroke.ConclusionLower serum levels of vitamin D3 and higher levels of uric acid were associated with ischemic stroke. There are still unknowns about the role of these indicators on ischemic stroke and it requires further studies.
Highlights
Cerebrovascular accident (CVA) is noted as the second cause of mortality, especially in the elderly population [1]
Results of the current study showed that serum phosphorus levels were not significantly predictive of ischemic stroke
Our study proved the results of recent studies regarding the role of vitamin D3 and serum uric acid level in the incidence of ischemic stroke
Summary
Cerebrovascular accident (CVA) is noted as the second cause of mortality, especially in the elderly population [1]. Talebi et al BMC Neurology (2020) 20:116 mediating factors such as vitamin D levels. Higher serum phosphate has been correlated with increased fibroblast growth factor-23 (FGF-23) activity [10]. FGF-23 suppresses serum levels of 1, 25-vitamin D3 by inhibiting the enzyme CYP27B1 (which converts 25-hydroxyvitamin D to 1, 25-dihydroxyvitamin D) [11]. Vitamin D insufficiency may activate parathyroid for releasing of parathyroid hormone [12] which was reported to elevate serum uric acid levels [13, 14], the exact mechanism is not clearly understood. Associations between serum phosphorus level and the incidence of ischemic stroke are not clear. This study aimed to measure serum phosphorus, vitamin D3, and uric acid levels in ischemic stroke patients compared to a population without ischemic stroke
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