Abstract
Abstract In 60 patients with definite multiple sclerosis (MS) correlations between the cerebrospinal fluid (CSF) IgG concentration, IgG/albumin ratio and electrophoretic findings (γ/β globulin ratio, number of bands representing oligoclonal gammopathy) and the percentage of CSF and peripheral blood (PB) rosetting T cells, T cell subpopulations (Fcγ cells, 0KT8+ and 0KT4+ cells) and PB B cells were studied. Examination of correlations between the quantitative and qualitative aspects of CSF gamma globulins and the proportion of CSF and PB immunocompetent cells represents a more sensitive indicator of ongoing immunopathologic mechanisms than comparison of the corresponding mean values in MS patients and controls. Because of the complexity of the correlations followed, a computer analysis is essential in their periodic evaluations.
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