Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress

Abstract

Sleep plays a critical role in body health maintenance and well-being throughout a lifetime. Sleeplessness is the most prevalent feature in the modernist societies, which impairs memory. Studies have shown a strong correlation between sleep deprivation and memory impairment in humans and animals, which is related to oxidative stress induced damage within the brain. Cerebrolysin (CBL) is a neuropeptide that is used to treat vascular dementia. In this study, the effect of CBL on sleep-deprivation induced memory impairment was investigated. Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks). Concurrently, CBL was administered intraperitoneally for four weeks. Animal's performance (spatial learning and memory) was assessed using the radial arm water maze (RAWM). Additionally, oxidative stress biomarkers including reduced glutathione (GSH), oxidized Glutathione (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), and catalase were assessed in the hippocampus. Current results showed that sleep deprivation impaired both short- and long- term memories (P < 0.05), and that chronic CBL administration prevented such impairment. Additionally, CBL prevented decreases in hippocampal GPx, catalase, GSH and GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by the sleep deprivation model (P < 0.05). In conclusion, result showed a protective effect for CBL administration against sleep-deprivation induced memory impairment, which could be related to CBL induced prevention of oxidative stress in the hippocampus.