Abstract
Objective:To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST).Methods:Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by magnetic resonance imaging (MRI) were analyzed retrospectively.Results:Among all researches, HBV surface antigen (HBsAg)-positive rate was high. Six of the 22 (27·3%) confirmed cases had HBsAg. However, HBsAg-positive rate in patients with ischemic stroke was only 45 of the 743 cases (6·1%), closed to the average prevalence in China (∼8·6%), but much lower than the positive rate in CVST patients (27·3 vs 6·1%, P = 0·002). Odd ratio (OR) value between HBsAg-positive CVST patients (27·3%) and HBsAg-positive ischemic stroke patients (6·1%) was 5·78. The OR value between HBsAg-positive CVST patients (27·3%) and average prevalence of HBV infection in China (8·6%) was nearly 3·99. It meant that HBV infection might be a risk factor for CVST. However, there existed no statistically significant difference in HBV surface antibody (HBsAb), HBV e antigen (HBeAg), HBV e antibody (HBeAb), and HBV central antibody (HBcAb)-positive rate. The HBV surface antigen (HBsAg)-positive CVST patients did not show worse liver function. Most of them were inactive HBV carriers.Conclusion:Hepatitis B virus infection may be a risk factor for CVST.
Published Version
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