Abstract
Among patients of different ages with hepatocirrhosis of A, B, C virus viral etiology in Child-Pugh, chronic hepatic encephalopathy of all stages may occur along with discirculatory disorders with the development of chronic cerebrovascular insufficiency. The Reitan test duration is more than 200 seconds, blood flow hemispheric asymmetry is more than 40%, the decrease in the velocity parameters of the blood flow and the indices of vascular resistance in the basins of the middle cerebral arteries decrease below the reference values are associated with the adverse hepatic encephalopathy prognosis. The degrees of cognitive and discirculatory disorders are interrelated with the compensation stages for hepatocirrhosis. An increase of cognitive impairment degree from the logical thinking ability and attention to time and space disorientation is registered along with discirculatory disorders and cirrhosis compensation stage decrease.
Highlights
Worldwide, there has been a steady increase in hepatocirrhosis cases with rapid disability of patients
There were no significant differences between the angleindependent indices for all hepatocirrhosis types and normal values, their reference values were within the normal range
With the hepatic encephalopathy stages increase, the middle cerebral artery blood flow hemispheric asymmetry increased, which was caused by the atherosclerosis process on the one hand, and on the other - by the lability of the vascular resistance due to vasoconstrictive substances, whose concentrations in the blood often increase with hepatocirrhosis and atherosclerosis, which was confirmed in other studies [1, 9At the same time, the non-dependent indices of vascular resistance decreased and were associated with the severity of hepatic encephalopathy and the stage of hepatocirrhosis compensation
Summary
There has been a steady increase in hepatocirrhosis cases with rapid disability of patients. Researches have been initiated for the past decades of hepatocirrhosis effect on the hepatic encephalopathy severity, etiology, disease stage, and psychological characteristics of the personality [5, 7, 11, 17]. Hepatic encephalopathy can be subclinical, but patients mortality is up to 10% and it is closely related with concomitant pathology, but not with portal hypertension complications [2, 14, 18, 19]. Despite numerous experimental and clinical studies on chronic hepatic encephalopathy, the mechanism of its development remains controversial and contradictory, and the effect of concomitant pathology on its clinical course and outcome is not excluded [3, 4, 10, 21]. International Journal of Infectious Diseases and Therapy 2018; 3(1): 18-23 divisions in case of hepatocirrhosis of types A, B and C on Child-Pugh viral etiology to determine the dyscirculatory disorders possible effects on the chronic hepatic encephalopathy clinical course and outcome
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