Abstract
Patients with cerebral gigantism have advanced linear growth and skeletal maturation, as well as mental retardation and characteristic facies. Two patients with these features have been studied. Both had dermatoglyphic abnormalities. Growth hormone concentrations were normal. The concentrations of essential amino acids in the plasma of these patients were considerably higher than those of control subjects. The ratios of glycine to valine and the ratios of other nonessential to essential amino acids were particularly effective in distinguishing patient from control. The data suggest that these ratios may be a meaningful way to assess cellular growth.
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