Cerebral Blood Flow Changes in Elderly Hypertensive Patients and Cognitive Functions

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HomeStrokeVol. 38, No. 11Cerebral Blood Flow Changes in Elderly Hypertensive Patients and Cognitive Functions Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBCerebral Blood Flow Changes in Elderly Hypertensive Patients and Cognitive Functions Dimiter Hadjiev, MD, PhD, DSc Petya Mineva, MD, PhD Dimiter HadjievDimiter Hadjiev University Hospital of Neurology and Psychiatry “St. Naum”, Medical University, Sofia, Bulgaria Search for more papers by this author Petya MinevaPetya Mineva Medical Faculty, Thracian University, Stara Zagora, Bulgaria Search for more papers by this author Originally published13 Sep 2007https://doi.org/10.1161/STROKEAHA.107.496919Stroke. 2007;38:e153Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: September 13, 2007: Previous Version 1 To the Editor:We read with interest the article by Beason-Held et al published in the June issue of Stroke.1 Fourteen treated hypertensive patients and 14 age-matched healthy controls, aged 70.8±7.4 SD years at entry, are examined. The authors, using repeated positron-emission tomography, have found that hypertension is associated with longitudinal regional cerebral blood flow (rCBF) changes, assessed over a period of 6 years, which differ from healthy controls. In hypertensive patients, greater rCBF decreases are observed in prefrontal, anterior cingulate, occipital areas and hippocampus in comparison with controls. However, relevant cognitive impairments are not demonstrated. The duration of hypertension is found to contribute significantly to the rCBF changes over time.Previous studies of the rCBF in hypertensive patients without cerebrovascular disease also report reductions in blood flow more marked in the frontal, temporal and parietal regions. The perfusion abnormalities are more severe in untreated, compared with treated subjects.2–4 It has been suggested that blood pressure control may preserve the global cerebral perfusion and reduce the cerebrovascular resistance.4In patients with essential hypertension, without a history of stroke, quantitative volumetric MRI shows atrophies in the thalamic nuclei and temporal lobes, attended with poor memory performance. It is also found that hypertension exacerbates the brain atrophies because of advanced age. The strongest interaction of age and hypertension has been observed in the temporal and occipital lobes.5 Besides, it has been shown that hypertension in older subjects without overt vascular disease is associated with cognitive impairment.6 It is also found that older hypertensive patients display a cognitive impairment more pronounced in those with poorly controlled blood pressure.7However, Beason-Held et al have not observed cognitive impairment in their hypertensive patients without other vascular risk factors, even in advanced age, although the blood pressure has not been adequately controlled. Undoubtedly, pathogenesis of vascular cognitive impairment is multifactorial, but the interaction of hypertension and age in their occurrence is well documented. The small sample size of this study has also hampered the evaluation of different antihypertensive drug effects over time. Because of a lack of MRI, cerebral small vessel lesions, often seen in hypertension, cannot be discussed. Despite the limitations of this study, the patterns of longitudinal rCBF changes in elderly hypertensive patients could be considered a subclinical stage of cognitive impairment.DisclosuresNone.1 Beason-Held LL, Moghekar A, Zonderman AB, Kraut MA, Resnick SM. Longitudinal changes in cerebral blood flow in the older hypertensive brain. Stroke. 2007; 38: 1766–1773.LinkGoogle Scholar2 Meyer JS, Rogers RL, Mortel KF. Prospective analysis of long term control of mild hypertension on cerebral blood flow. Stroke. 1985; 16: 985–990.CrossrefMedlineGoogle Scholar3 Rodriguez G, Arvigo F, Marenco S, Nobili F, Romano P, Sandini G, Rosadini G. Regional cerebral blood flow in essential hypertension: data evaluation by a mapping system. Stroke. 1987; 18: 13–20.CrossrefMedlineGoogle Scholar4 Nobili F, Rodriguez G, Marenco S, De Carli F, Gambaro M, Castello C, Pontremoli R, Rosadini G. Regional cerebral blood flow in chronic hypertension: a correlative study. Stroke. 1993; 24: 1148–1153.CrossrefMedlineGoogle Scholar5 Strassburger TL, Lee HC, Daly EM, Szczepanik J, Krasuski JS, Mentis MJ, Salerno JA, DeCarli C, Schapiro MB, Alexander GE. Interactive effects of age and hypertension on volumes of brain structures. Stroke. 1997; 28: 1410–1417.CrossrefMedlineGoogle Scholar6 Harrington F, Saxby BK, McKeith IG, Wesnes K, Ford GA. Cognitive performance in hypertensive and normotensive older subjects. Hypertension. 2000; 36: 1079–1082.CrossrefMedlineGoogle Scholar7 Waldstein SR, Brown JR, Maier KJ, Katzel LI. Diagnosis of hypertension and high blood pressure levels negatively affect cognitive function in older adults. Ann Behav Med. 2005; 29: 174–180.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Hadjiev D and Mineva P (2008) Antihypertensive treatment in elderly hypertensives without a history of stroke and the risk of cognitive disorders, Acta Neurologica Scandinavica, 10.1111/j.1600-0404.2008.01001.x, 118:3, (139-145), Online publication date: 1-Sep-2008. November 2007Vol 38, Issue 11 Advertisement Article InformationMetrics https://doi.org/10.1161/STROKEAHA.107.496919PMID: 17872476 Originally publishedSeptember 13, 2007 PDF download Advertisement