Abstract
Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies.
Highlights
Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people
These arteries are the largest in the brain and their architectonics is available for study by Magnetic Resonance Imaging (MRI) methods
We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the major blood vessels of the brain as the disease progresses
Summary
Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling This may be of extensive interest, in pharmacological and preclinical studies. It is natural to assume that with the course of the disease leading to changes in the functioning of the circulatory system and the need for its adaptation there may be a change in the geometry and hemodynamic regime of this arterial complex. These arteries are the largest in the brain and their architectonics is available for study by Magnetic Resonance Imaging (MRI) methods
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