Cerebral abscesses in Marfan’s disease

Abstract

A 43-years-old woman was hospitalized with headaches progressing over the 10 preceding days and an epileptic seizure. The patient had a Marfan disease which required two cardiac surgeries - the last one in 2014 with the installation of an aortic tube and a mechanical aortic valve. A gadolinium-enhanced magnetic resonance image of the brain was performed and revealed numerous lesions, some with ring enhancement, substantial edema but without mass effect (Figure 1). Additional tests were carried out including blood cultures, transthoracic and trans-oesphageal echocardiogram, Coxiella burnetii, Bartonella spp. and Mycoplasma pneumonia serologies that remained all negative. After 48 h incubation of CT-guided brain abscess aspiration, small yellow colonies appear on chocolate blood agar and Gram staining shows small Gram-negative bacilli (Figures 2,3). Identification realized by MALDI-TOF mass spectrometry revealed Aggregatibacter aphrophilus. Blood cultures remained sterile.