Cereal bran extracts inhibit the formation of advanced glycation endproducts in a bovine serum albumin/glucose model

Abstract

AbstractBackground and objectivesThe adverse health effects of advanced glycation endproducts (AGEs) is of current interest; some previous research indicates that consuming these compounds may contribute to chronic diseases such as diabetes and heart disease. The objective of this study was to determine whether cereal bran extract from wheat (Jagger, JA), triticale (Spring Triticale, ST, and Thundercale, TH), and Rye (RY) can inhibit the formation of AGE in a bovine serum albumin/glucose (BSA/GLU) model.FindingsNε‐carboxymethyllysine (CML) levels showed ST extract inhibited AGE formation, but TH, RY, and JA extracts did not affect AGE formation in the BSA/GLU system. Subsequent HPLC analysis of ST extract revealed four major phenolic acids: vanillic (VA), chlorogenic (CHA), gentisic (GEA), and ferulic (FA). The results also showed antioxidant and antiglycation properties of these phenolic acids.ConclusionsGEA and CHA in ST extract were effective free radical scavengers and acted against dicarbonyl compounds.Significance and noveltyST bran extract may be considered as a natural source of inhibitors of in vitro formation of AGEs.