Abstract
Two previously undescribed ceramides, named celtisamide A ( 1 ) and B ( 2 ), along with 16 known compounds ( 3 - 18 ), were isolated both from the stem bark and roots of Celtis tessmannii Rendle. The isolated compounds were assessed in vitro for their DPPH radical scavenging, antiplasmodial activity as well as their urease and lipoxygenase inhibitory properties. In addition, fractions and extracts were also evaluated for antiplasmodial and cytotoxicity activities against HEK293T. Cis -1- O -methylinositol ( 17 ) (IC 50 = 14.3 µ M) was the most potent inhibitor of urease, while succinic acid ( 18 ) (IC 50 = 12.9 µ M) exhibited the best inhibition against lipoxygenase. Compound 18 (IC 50 = 9.5 µ M) showed the best DPPH radical scavenging activity. Extracts and fractions exhibited varying degree of antiplasmodial potency with IC 50 values ranging from 2.42-100.00 µ g/mL, while betulinic acid ( 7 ) showed potency with IC 50 values ranging from 1.87-2.34 µ g/mL against Chloroquine-sensitive ( Pf 3D7), and Chloroquine-resistant ( Pf Dd2 and Pf INDO) strains of Plasmodium falciparum .
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