Centrosomes failure to engage to the spindle and peri-centrosome fragmentation is a frequent phenotype in the first cell division of non-rodents mammalian zygotes

Abstract

Background and Aim: Post-zygotic or “mosaic” aneuploidy, aka the presence of a subset of cells with an aberrant number of chromosomes, is a frequent feature of human preimplantation embryos. A high incidence of aneuploidy within an embryo is recognized as the major cause of developmental arrest and miscarriage. Post-zygotic aneuploidy often arises during the zygotic division and it is not only exclusive of human embryos, but has a similar occurrence in nonhuman primate, bovine, and equine embryos.