Abstract
SummaryThe ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in 2016. Since then, rapid progress has been made in research areas related to in vitro culture of human embryos, creation of stem cell-based embryo models, and in vitro gametogenesis. Therefore, a working group of international experts was convened to review the oversight process and provide an update to the guidelines. This report captures the discussion and summarizes the major recommendations made by this working group, with a specific emphasis on updating the categories of review and engagement with the specialized scientific and ethical oversight process.
Highlights
Framing the issues The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in 2016
It was already recognized that the ethical issues related to human embryo research extended well beyond the use of human embryos for generation of embryonic stem cells (ESCs)
The use of human gametes differentiated from stem cells for the purposes of human reproduction currently falls under a prohibited activity, category 3A, as the committee decided that safety issues around this technology remain to be resolved
Summary
Stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines. Clark,1,* Ali Brivanlou, Jianping Fu, Kazuto Kato, Debra Mathews, Kathy K.
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