Abstract
A lower dissolution rate of poorly soluble drugs is the prime factor aff ecting their bioavailability. The centrifugal melt spinning method is a simple, aff ordable and scalable technique to prepare microfi bers with enhanced solubility and dissolution rate. This study aimed to enhance the solubility and dissolution rate of poorly soluble drug diclofenac sodium by centrifugal melt spinning technique. Microfi brous solid dispersion of diclofenac sodium 10% w/w with sucrose were prepared to utilize a cotton candy device. The dissolution studies revealed that the drug-loaded microfi bers released 98.10 ± 0.52% of drug within 5 minutes as compared with pure drug and physical mixture. The drug-loaded microfi bers were bead-free with uniform morphology and diameter of 13.25 ± 4.4 μm. The centrifugal melt-spinning process converted the drug and carrier to amorphous state, which was further confi rmed from the calorimetric and crystallographic study results. The results indicated that the centrifugal melt spinning process rapidly produced microfi bers with improved solubility and dissolution rate. The results of this study have shown that the centrifugal melt spinning technique may provide an easy, highly scalable, and adaptable fabrication technique to increase the solubility and rate of dissolution of poorly soluble drugs.
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