A mini review on centrifugal spinning technique for production of nanofibers and its applications in drug delivery

Abstract

Nanofibers possess distinctive physicochemical and biological properties and have been utilized in a wide range of research and commercial applications. Electrospinning is a widely used technology for generating nanofibers, but due to its low production rate, it lacks scalability. Centrifugal spinning is a low-cost process for producing nanofibers that is simple, quick, and scalable. It has emerged as a potential technology for fabricating nanofibers with a variety of applications due to its extremely high production rate and multifaceted features. The centrifugal spinning process involves injecting the polymer solution or melt in a rotating spinneret. When the spinning head reaches a critical speed, the centrifugal force overcomes the surface tension of the spinning liquid, and a liquid jet ejects from the nozzle tip. The jet is then stretched further, resulting in solidified nanofibers on the collector. The technique is capable of producing 3D nanofiber scaffolds from various polymers for biomedical applications. This paper describes in details the centrifugal spinning process, its classification, principle and applications of the centrifugal spun nano/micro fibers in drug delivery and wound dressing. Keywords: Nanofibers, Centrifugal spinning, Solubility enhancement, drug delivery.