Abstract
BackgroundTo evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diabetic retinopathy (DR).MethodsCross sectional study including consecutive patients of type 2 diabetes mellitus [without DR (No DR, n = 97); non-proliferative DR (NPDR, n = 91); proliferative DR (PDR, n = 83)] and healthy controls (n = 82) was undertaken. CST and CAT values were measured using SD-OCT. Data was analyzed using Chi square test, ANOVA and multivariate analysis. Discriminant values of CST and CAT for EZ disruption were evaluated using receiver operator characteristic curve. Area under curve (AUC) was computed.ResultsMean CAT and CST values in the study subjects showed an incremental trend. Multivariate ordinal logistic regression analysis showed increase in CST (OR = 1.022, p < 0.001) and CAT (OR = 1.029, p < 0.001) as significant independent predictors of EZ disruption. Area under curve showed excellent predictive results of CST (AUC = 0. 943 ± 0.021, 95% CI, 0.902–0.984, p < 0.05) and CAT (AUC = 0.959 ± 0.012, 95% CI 0.936–0.982, p < 0.05), as bioimaging biomarkers, for EZ disruption.ConclusionIncrease in CST and CAT is associated with increased odds of EZ disruption and these macular parameters serve as bioimaging biomarkers for EZ disruption in DR.
Highlights
To evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diabetic retinopathy (DR)
Based on the fundus photography and fluorescein angiography, subjects were divided into three groups according to the early treatment of diabetic retinopathy study (ETDRS) classification [11]: diabetes mellitus patients without retinopathy (No DR, n = 97), with nonproliferative diabetic retinopathy (NPDR, n = 91), and with proliferative diabetic retinopathy (PDR, n = 83)
analysis of variance (ANOVA) showed no difference in age among the study groups (F = 1.66, P = 0.183)
Summary
To evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diabetic retinopathy (DR). Approximately 90 million people in the world suffer from DR [1]. The prevalence of DR is expected to rise to 592 million by 2035 [2]. Spectral domain Optical coherence tomography (SDOCT) provides high resolution structural images with precise retinal thickness measurements [4]. It is the technique of choice for early detection of macular edema and for follow-up of diabetic maculopathy. The OCT based macular thickness parameters, namely central subfield thickness (CST) and cube average thickness (CAT) have recently been
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