Central Obesity, Inflammation and Angiogenesis in Adult Men

Abstract

AbstractObesity is known to link with low-grade inflammation. Experimental studies revealed that inflammation was associated with angiogenesis process in adipose tissue. We investigate the correlation between inflammation and angiogenesis in Indonesian adult men with central obesity. A cross-sectional study was undertaken on 161 healthy Indonesian adult men (age: 23-53 y, waist circumference: 64-125 cm). Clinical parameters; biochemical markers; anthropometric parameters (weight, height and abdominal circumference); inflammatory biomarkers (tumor necrosis factor-α (TNF-α) and its soluble tumor necrosis factor receptor-2 (sTNFR-2), interleukin (IL)-1β); and biomarkers of angiogenesis (leptin, vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and Ang-2 were measured. Obese II, Obese I subjects had higher concentrations of fasting blood glucose and triglycerides (P<0.005) than those Non-obese subjects. Obese II subjects had higher concentrations of hsCRP (P<0.05) than obese I subjects; and obese I subjects had higher concentration of hsCRP (P<0.05) than Non-obese subjects. sTNFR-2 correlated positively with leptin and Ang-2 (rs = 0.376, P< 0.001 and rs = 0.281, P = 0.003, respectively) and negatively with Ang-1 in obese subjects. High concentration of sTNFR-2 also correlated with increased concentrations of leptin, VEGF and Ang-2 in all subjects (P= 0.001, P= 0.033, and P= 0.005, respectively). In obese subjects, high concentration of sTNFR-2 had correlated with increased leptin and Ang-2, and decreased Ang-1 (7.4 %, 10.9% and 9.2%, respectively). This study was able to demonstrate the relations between inflammation and angiogenesis in Indonesian adult men with central obesity. Findings of this study suggest that inflammation and angiogenesis were mutually supportive processes contribute to systemic low grade inflammation in central obesity.