Abstract
Primary angle-closure glaucoma (PACG) is highly prevalent in Asian countries, compared with primary open-angle glaucoma (POAG), which is reported predominant disease among Whites and that is the reason for paucity of reports about central corneal thickness (CCT) and corneal curvature (CC) in eyes with PACG in Europe. To determine central corneal thickness, corneal curvature and refractive error in patients with primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG). A total of 288 patients were enrolled into this study; 132 patients with PACG (mean age of 73 ± 7 years) compared with 156 patients with POAG (mean age of 70 ±7 years). The data was collected from all PACG patients who underwent Laser peripheral iridotomy at the Clinic for Eye Diseases, Clinical Center of Serbia in Belgrade between January 2012 and October 2012 and controls with POAG examined in the same period. Data from the right eye was used for analysis. In PACG/POAG mean CCT was 549±38/547±35 μm (p=0.353) and mean radius of corneal curvature (Cr) was 7.92±0.22/7.75±0.29 mm (p=0.003). There was no statistically significant correlation between IOP and mean Cr in PACG (p=0.244 ) and POAG ( p=0.637) while it was in POAG group with refractive error (p=0.005) and CCT (p<0.001). We found that CCT in PACG and POAG group were in normal range and there was no diference between them. Our results showed that the eyes with PACG had the flatter corneas than eyes with POAG and were hyperopic.
Highlights
Primary angle-closure glaucoma (PACG) is highly prevalent in Asian countries, compared with primary open-angle glaucoma (POAG), which is reported predominant disease among Whites [1]
Earlier studies have identified that central corneal thickness (CCT) has significant effect on intraocular pressure (IOP) values measured with Goldmann applanation tonometry (GAT); true IOP in eyes with thicker corneas is lower than that is measured and thinner corneas lead to lower readings
There were statistically significant difference between PACG and POAG group regarding to sex and no difference regard to IOP, in group with PACG, IOP was 17 ± 3 mmHg and in group POAG was 18 ± 4 mmHg
Summary
Primary angle-closure glaucoma (PACG) is highly prevalent in Asian countries, compared with primary open-angle glaucoma (POAG), which is reported predominant disease among Whites [1]. The prevalence of PACG in Europe is 0.1 % [2]. The Egna –Neumarkt Glaucoma Study stated that the burden of PACG in Europe has been underestimated previously [3]. The role of central corneal thickness (CCT) measerment in clinical evaluation in glaucoma is established [5]. Earlier studies have identified that CCT has significant effect on intraocular pressure (IOP) values measured with Goldmann applanation tonometry (GAT); true IOP in eyes with thicker corneas is lower than that is measured and thinner corneas lead to lower readings. Besides CCT, the accuracy of GAT depends on many other factors including corneal curvature, corneal structure and axial length [6]. Corneal curvature (CC) is another factor affecting IOP and CCT readings
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