Abstract
Cellular Responses of Mouse Vaginal Cells Treated with Korean Native Plant Extracts
Highlights
Proliferating Cell Nuclear Antigen (PCNA), one of the cell activating factors, is a major marker for cell survival (Liu et al, 2018)
January 2020 | Volume 8 | Issue 1 | Page 27 fect of Semaphorin 4D on vaginal epithelial cell apoptosis and suggested that the expression of Caspase-3 is highly influenced by this agent
D2 showed a serious cell rupture pattern by necrosis. Plant extracts showed both hypertrophy and hyperplasia, which implies that the cell tends to control their functionality and structural forms to survive against the different types of injury
Summary
Proliferating Cell Nuclear Antigen (PCNA), one of the cell activating factors, is a major marker for cell survival (Liu et al, 2018). The expression of PCNA in uterus and mammary gland by the treatment of isoflavone genistein has been previously reported (Rimoldi et al, 2007; Al-Snafi 2018; IIhsan et al, 2019). Glover et al (2017) reported that PCNA is a major protein influencing DNA replication, repair of DNA damage, chromatin structure maintenance, chromosome segregation and cell-cycle progression in cancerous cells. Dendropanax morbifera Levillis is a native Korean plant and is mostly growing in southern parts of Korea (Youn et al, 2019). Koreans have strong belief on medicinal plants the health effects of this plant. The effects of D. morbifera are numerously published for their medicinal purposes and other daily applications as a healthy food (Song et al, 2019). The effects of D. morbifera are numerously published for their medicinal purposes and other daily applications as a healthy food (Song et al, 2019). Kim et al (2017) reviewed various effects of this plant as anti-cancer and anti-oxidant espe-
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