Abstract
In this study, the cellular protective effect of resveratrol on oxidative damage and its antioxidative activity were investigated. The free radical-scavenging activity () of resveratrol was measured to be . The reactive oxygen species-scavenging activity () of resveratrol on the ROS generated in a system was investigated using the luminol-dependent chemiluminescence assay. Resveratrol displayed ROS scavenging activity, which is 9.6-fold higher than that of L-ascorbic acid () and had a more prominent cellular protective effect than (+)--tocopherol. When HaCaT cells were exposed to of UVB or treated with rose bengal, resveratrol protected the cells against oxidative stress in a concentration-dependent manner; however, it was unable to protect the cells when the damage was induced by 10 mM . These results indicate that resveratrol could be employed to improve and prevent the skin aging through its antioxidative and cellular protective activities.
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