Abstract
Methods 11 mice underwent transverse aortic constriction (TAC). All mice were imaged at baseline, and a group of mice were examined early (2 weeks), intermediate (4 weeks) and late (7 weeks) post-TAC with histologic correlation. Mice were imaged at 9.8 Tesla with standard cine function sequences and T1 quantification via a Look-Locker cine experiment, pre and post gadolinium. The intra-cellular lifetime of water (τic), a-cell size dependent parameter, and the extracellular volume fraction (ECV) were determined by fitting R1 in tissue, against R1 in the blood pool, with a 2-site model for transcytolemmal water exchange. Minor (Dmin) and major (Dmaj) cell-diameters were determined by image analysis of FITC-wheat germ agglutinin stained sections.
Highlights
Hypertension is a major risk factor for diastolic heart failure
Cellular hypertrophy occurs before interstitial fibrosis in pressure-overload heart failure
transverse aortic constriction (TAC) was associated with a significant decrease in LVEF
Summary
Cellular hypertrophy occurs before interstitial fibrosis in pressure-overload heart failure. Ravi Shah1*, Otavio R Coelho-Filho, Richard N Mitchell, Raymond Y Kwong, Saumya Das, Anthony Rosenzweig, Michael Jerosch-Herold. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013
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